2021 - Present


2011 - 2020

 

Christen U, Kimmel R. (2020)
Chemokines as Drivers of the Autoimmune Destruction in Type 1 Diabetes: Opportunity for Therapeutic Intervention in Consideration of an Optimal Treatment Schedule.
Front. Endocrinol. 11:591083

Schwarzkopf KM, Eberle L, Uschner FE, Klein S, Schierwagen R, Mücke MM, Schaefer L, Clària J, Zeuzem S, Hintermann E, Christen U, Lange CM, Trebicka J, Welsch C (2020) Interleukin-22 in acute-on-chronic liver failure: A matter of ineffective levels, receptor dysregulation or defective signalling?
J Hepatol. 73(4):980-982 


Christen U. (2020)
Breakdown of tolerance in autoimmune hepatitis: This time toxin beats virus.
Immunol Lett. 218:51-53 


Umeshappa CS, Mbongue J, Singha S, Mohapatra S, Yamanouchi J, Lee JA, Nanjundappa RH, Shao K, Christen U, Yang Y, Ellestad KK, Santamaria P. (2020)
Ubiquitous antigen-specific T regulatory type 1 cells variably suppress hepatic and extrahepatic autoimmunity.
J Clin Invest. 130:1823-1828 

 

Fuchs S, Bayer M, Taubert R, Manns MP, Pfeilschifter JM, Christen U, Hintermann E. (2019) Effects of adenovirus-induced hepatocyte damage on chronic bile duct inflammation in a sclerosing cholangitis mouse model.
Liver Int. 39:2330-2340 

 

von Knethen A, Schäfer A, Kuchler L, Knape T, Christen U, Hintermann E, Fißlthaler B, Schröder K, Brandes RP, Genz B, Abshagen K, Pützer BM, Sha LK, Weigert A, Syed SN, Schulz M, Shah AM, Ernst A, Putyrski M, Finkelmeier F, Pesic M, Greten F, Hogardt M, Kempf VAJ, Gunne S, Parnham MJ, Brüne B. (2019)
Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis.
Theranostics 9:2003-2016 

 

Hintermann E, Christen U. (2019)
The Many Roles of Cell Adhesion Molecules in Hepatic Fibrosis.

Cells 8: E1503 

 

Violatto MB, Casarin E, Talamini L, Russo L, Baldan S, Tondello C, Messmer M, Hintermann E, Rossi A, Passoni A, Bagnati R, Biffi S, Toffanin C, Gimondi S, Fumagalli S, De Simoni MG, Barisani D, Salmona M, Christen U, Invernizzi P, Bigini P, Morpurgo M. (2019) Dexamethasone Conjugation to Biodegradable Avidin-Nucleic-Acid-Nano-Assemblies Promotes Selective Liver Targeting and Improves Therapeutic Efficacy in an Autoimmune Hepatitis Murine Model.
ACS Nano. 13: 4410-4423.
 

Christen U. (2019)
Pathogen infection and autoimmune disease.
Clin Exp Immunol. 195:10-14.

Christen U and Hintermann E. (2019)
Pathogens and autoimmune hepatitis.
Clin Exp Immunol. 195:35-51. 


Christen U. (2019)
Animal models of autoimmune hepatitis.
Biochim Biophys Acta Mol Basis Dis. 1865:970-981 

 

Kalamakis G, Brüne D, Ravichandran S, Bolz J, Fan W, Ziebell F, Stiehl T, Catalá-Martinez F, Kupke J, Zhao S, Llorens-Bobadilla E, Bauer K, Limpert S, Berger B, Christen U, Schmezer P, Mallm JP, Berninger B, Anders S, Del Sol A, Marciniak-Czochra A, Martin-Villalba A. (2019) Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain.
Cell. 176: 1407-1419. 

 

Hintermann E, Bayer M, Conti CB, Fuchs S, Fausther M, Leung PS, Aurrand-Lions M, Taubert R, Pfeilschifter JM, Friedrich-Rust M, Schuppan D, Dranoff JA, Gershwin ME, Manns MP, Imhof BA, Christen U. (2018)
Junctional adhesion molecules JAM-B and JAM-C promote autoimmune-mediated liver fibrosis in mice.
J Autoimmun. 91:83-96. 

 

Goren, I., Christen, U., Pfeilschifter, J., and Frank, S. (2018)
A heterogeneous Ly-6B2+ leukocyte population consists of yet undescribed iNOS-expressing cell types in murine skin wounds.
Nitric Oxide. 74:23-31 


Christen, U. and Hintermann, E. (2018)
Autoantibodies in autoimmune hepatitis: Can epitopes tell us about the etiology of the disease?
Front. Immunol 9: 163 


Nastase, M.V., Zeng-Brouwers, J., Beckmann, J., Tredup, C., Christen, U., Radeke, H.H., Wygrecka, M., and Schaefer, L. (2018)
Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney. 

Matrix Biol. 68/69:293-317 

 

Honke, N., Shaabani, N., Teijaro, J.R., Christen, U., Hardt, C., Bezgovsek, J., Lang, P.A., and Lang, K.S. (2017)
Presentation of Autoantigen in Peripheral Lymph Nodes Is Sufficient for Priming Autoreactive CD8+ T Cells.
Front. Immunol. 8:113. 

 

Bonvin, P., Gueneau, F., Buatois, V., Charreton-Galby, M., Lasch, S., Messmer, M., Christen, U., Luster, A.D., Johnson, Z., Ferlin, W., Kosco-Vilbois, M., Proudfoot, A., and Fischer, N. (2017)
Antibody neutralization of CXCL10 in vivo is dependent on binding to free and not endothelial-bound chemokine: Implications for the design of a new generation of anti-chemokine therapeutic antibodies.
J Biol Chem. 292:4185-4197. 

 
Bender, C., Christen, S., Scholich, K., Bayer, M., Pfeilschifter, J.M., Hintermann, E., Christen, U. (2017)

Islet-expressed CXCL10 promotes autoimmune destruction of islet iso-grafts in mice with type 1 diabetes.

Diabetes 66:113-26


Hintermann, E., Bayer, M., Ehser, J., Aurrand-Lions, M., Pfeilschifter, J.M., Imhof, BA., Christen, U. (2016)

Murine junctional adhesion molecules JAM-B and JAM-C mediate endothelial - and stellate cell interactions during hepatic fibrosis.

Cell. Adh. Migr.10: 419-433


Müller, P., Messmer, M., Bayer, M., Pfeilschifter, J.M., Hintermann, E., Christen, U. (2016)

Non-alcoholic fatty liver disease (NAFLD) potentiates autoimmune hepatitis in the CYP2D6 mouse model.

J. Autoimmun 69: 51-58

 

Berner, A., Bachmann, M., Bender. C., Pfeilschifter, J.M., Christen, U., Mühl, H., (2016)

Though active in RINm5F insulinoma cells and cultured pancreatic islets, recombinant IL-22 fails to modulate cytotoxicity and disease in a protocol of streptozotocin-induced experimental diabetes.

Front. Phramacol. 6: 317.


Christen, U. and Hintermann, E. (2016)
Immunopathogenic Mechanisms of Autoimmune Hepatitis: How Much Do We Know from Animal Models?
Int J Mol Sci. 17 :E2007 

Lasch, S., Müller, P., Bayer, M., Pfeilschifter, J.M., Luster, A.D., Hintermann, E., and Christen, U. (2015) 

Anti-CD3/anti-CXCL10 antibody combination therapy induces a persistent remission of type 1 diabetes in two mouse models.

Diabetes 64: 4198-4211


Shaabani, N., Khaimar, V., Duhan, V., Zhou, F., Tur, R.F., Häussinger, D., Recher, M., Tumanov, A.V., Hardt, C., Pinschewer, D., Christen, U., Lang, P.A., Honke, N., and Lang, K.S. (2015)

Two separate mechanisms of enforced viral replication balance innate and adaptive immune activation.

J. Autoimmun. 67: 82-89


Christen, U. (2015)

An update on animal models for autoimmune hepatitis: Are we there yet?

Curr. Pharm. Des. 21: 2391-2400.


Christen, U. (2015)

CXCR3 ligands.

In: Encyclobedia of Inflammatory Diseases, Springer Verlag, Germany (ed: Michael Parnham).

 

Hintermann, E., Bayer. M., Pfeilschifter, J.M., Deak, F., Kiss, I., Paulsson, M., and Christen, U. (2015)

Upregulation of matrilin-2 expression in murine hepatic stellate cells during liver injury has no effect on fibrosis formation and resolution.

Liver Int. 35: 1265-1273.


Christen, U. (2014)

Pathogen infection and autoimmunity.

Int. Rev. Immunol 33: 261-265.

 

Christen, U. and Hintermann, E (2014)

Pathogen infection and autoimmune hepatitis.

Int. Rev. Immunol. 33: 296-313.

 

Bender, C., Schlosser, M., Christen, U., Ziegler, G.A., and Achenbach, P. (2014)

GAD autoantibody affinity in schoolchildren from the general population.

Diabetologia 57: 1911-1918.


Christen U. (2013)

Molecular mimicry.

In: Autoantibodies (3rd edition), Elsevier, Amsterdam, The Netherlands (eds. Yehuda Shoenfeld, Pier-Luigi Meroni, M. Eric Gershwin).

 

Christen U., and von Herrath M.G. (2013)

Virus-induced mouse models for type 1 diabetes.

In: Diabetes and Viruses, Springer Verlag, Germany (eds: Keith Taylor, Heikki Hyöty, Antonio Toniolo and Arie Zuckerman).

 

Hintermann, E., Ehser, J., Bayer, M., Pfeilschifter, J.M., and Christen, U. (2013)

Induction of hepatic fibrosis by an adenovirus encoding the human liver autoantigen Cytochrome P450 2D6.

J. Autoimmun. 44: 49-60.


Coppieters, KT., Amirian, N., Pagni, P.P., Jones, C.B., Wiberg, A., Lasch, S., Hintermann, E., Christen, U,. and von Herrath, M.G. (2013)

Functional redundancy of CXCR3/CXCL10 signalling in the recruitment of diabetogenic CTL to pancreatic islets in a virally induced autoimmune diabetes model.

Diabetes 62: 2492-2499.


Ehser, J., Holdener, M., Christen, S., Bayer, M., Pfeilschifter, J.M., Hintermann, E., Bogdanos, D., and Christen, U. (2013)

Molecular mimicry rather than identity breaks T-cell tolerance in the CYP2D6 mouse model for human autoimmune hepatitis.

J. Autoimmun. 42: 39-49.


Christen U. (2013)

The role of antibodies in autoimmune hepatitis type 2: Diagnosc markers, pathogenic triggers or therapeutic agents?

Future Medicine: Immunotherapy 5: 247-256.

 

Christen, S., Christen, S., Coppieters, K., Rose, K., Holdener, M., Bayer, M., Pfeilschifter, J.M., Hintermann, E., von Herrath, M.G., Aurrand-Lions, M., Imhof, B.A., and Christen, U. (2013)

Blockade but not overexpression of the junctional adhesion molecule C influences virus-induced type 1 diabetes in mice.

PLOS ONE 8: e54675.


Rose, K., Penna-Martinez, M., Klahold, E., Kärger, D., Shoghi, F., Kahles, H., Bayer, M., Hintermann, E., Pfeilschifter, J.M., Badenhoop, K., Ramos-Lopez, E., and Christen U. (2013)

Influence of the vitamin D plasma level and vitamin D related genetic polymorphisms on the immune status of patients with type 1 diabetes: A pilot study.

Clin. Exp. Immunol. 171: 171-185.


Christen U, Bender C, von Herrath MG. (2012)

Infection as a cause of type 1 diabetes?

Curr Opin Rheumatol. 24:417-23.

 

Hintermann E, Ehser J, and Christen U. (2012)

The CYP2D6 animal model: how to induce autoimmune hepatitis in mice.

J. Vis. Exp. 60: e3644 1-7.

Link to video paper: 

 

Hintermann, E., Holdener, M., Bayer, M., Loges, S., Pfeilschifter, J.M., Granier, C., Manns, M.P., and Christen, U. (2011)

Epitope spreading of the anti-CYP2D6 antibody response in patiemts with autoimmune hepatitis and in the CYP2D6 mouse model.

J. Autoimmun. 37:242-253.


Christen, S., Holdener, M., Beerli, C., Thoma, G., Bayer, M., Pfeilschifter, J.M., Hintermann, E., Zerwes, H.G. and Christen, U. (2011)

Small molecule CXCR3 antagonist NIBR2130 has only a limited impact on type 1 diabetes in a virus-induced mouse model.

Clin. Exp. Immunol.165:318-328.

 

Christen, U. and von Herrath, M.G. (2011)

Do virus infections protect from or enhance type 1 diabetes and how can we tell the difference?

Cell. Mol. Immunol. 8: 193-198

2001 - 2010


Hintermann, E., Bayer, M., Pfeilschifter, J.M., Luster, A.D., and Christen, U. (2010)

CXCL10 promotes liver fibrosis ny prevention of NK cell mediated hepatic stellate cell inactivation.

J. Autoimmun. 35: 424-435

  

Christen, U. (2010)

Enterovirus infection of human beta-cells activates dendritic cells and triggers antiviral responses: are enteroviruses convicted now?

Diabetes 59: 1126-1128

  

Bachmann, M., Horn, K., Rudloff, I., Goren, I., Holdener, M., Christen, U., Darsow, N., Hunfeld, K.P., Koehl, U., Kind, P., Pfeilschifter, J., Kraiczy, P., and Mühl, H. (2010)

Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1.

PLoS Pathog. 14: 6(10)

  

Christen, U., Holdener, M., and Hintermann, E. (2010)

Cytochrome P450 2D6 as a model antigen.

In: Immunology and Liver Disease - Proceedings of the Falk Symposium

Dig. Dis. 28: 80-85

 

Christen, U., Hintermann, E., Holdener, M., and von Herrath, M.G. (2010)

Viral triggers for autoimmunity: Is the glass of molecular mimicry half full or half empty?

J. Autoimmun. 34: 38-44

 

Horwitz, M., Efrat, S., Christen, U., von Herrath, M.G., and Oldstone, M.B.A. (2009)

Adenovirus E3 MHC inhibitory genes but not TNF/Fas apoptotic inhibitory genes expressed in beta-cells prevent autoimmune diabetes.

Proc. Nat. Acad. Sci. 106: 19450-19454.

 

Christen, U., Hintermann, E., and Jaeckel, E. (2009)

New animal models for autoimmune hepatitis.

Semin. Liver Dis. 29: 262-272

 

Holdener, M., Hintermann, E., Bayer, M., Rhode, A., Rodrigo, E., Hintereder, G., Johnson, E.F., Gonzalez, F.J., Pfeilschifter, J., Manns, M.P., von Herrath, M.G., and Christen, U. (2008)

Breaking tolerance to the natural human liver autoantigen Cytochrome P450 2D6 by virus infection.

J. Exp. Med. 205: 1409-1422


Bogdanos, D.P.B. and Christen, U. (2008)

Autoimmune Hepatitis: An Update on Current Animal Models.

The Open Pathology Journal 2: 39-45

 
Lastres-Becker, I., Brodesser, S., Lütjohann, D., Azizov, M., Buchmann, J., Hintermann, E., Sandhoff, K., Schürmann, A., Nowock, J., Auburger, G. (2008)

Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice.

Hum Mol Genet. 15: 1465-1481.

Fink K, Zellweger R, Weber J, Manjarrez-Orduno N, Holdener M, Senn BM, Hengartner H, Zinkernagel RM, Macpherson AJ. (2008)

Long-term maternal imprinting of the specific B cell repertoire by maternal antibodies.

Eur J Immunol. 38: 90-101. 


Hintermann, E. and Christen, U. (2007)

Viral infection – a cure for type 1 diabetes?

Current Medicinal Chemistry14: 2048-2052.

Christen, U., Holdener, M. and Hintermann, E., (2007)

Animal Models for Autoimmune Hepatitis.

Autoimmunity Reviews 6: 306-311.

Christen, U. (2007)

Chemokines as drug targets in type 1 diabetes.

Endocr Metab Immune Disord Drug Targets 7: 7-12.

Goren, I., Muller, E., Schiefelbein, D., Christen, U., Pfeilschifter, J., Muehl, H. and Frank, S. (2007)

Systemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages.

J. Invest. Dermatol. 127: 2259-2267.

Martinic, M.M., Juedes, A.E., Bresson, D., Homann, D., Skak, K., Huber, C., Ling, E., Ejrnaes, M., Wolfe, T., Togher, L., Christen, U., and von Herrath, M.G. (2007)

Minimal impact of a de-novo expressed b-cell autoantigen on spontaneous diabetes development in NOD mice.

Diabetes 56: 1059-1068.

Ejrneas, M. von Herrath, M.G. and Christen, U. (2006) 

Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies.

Clin. Develop. Immunol. 13: 67-77.

Fink K, Lang KS, Manjarrez-Orduno N, Junt T, Senn BM, Holdener M, Akira S, Zinkernagel RM, Hengartner H. (2006)

 Early type I interferon-mediated signals on B cells specifically enhance antiviral humoral responses.

Eur J Immunol. 36(8):2094-105.

von Allmen N, Christen S, Forster U, Gottstein B, Welle M, Muller N. (2006)

Acute trichinellosis increases susceptibility to Giardia lamblia infection in the mouse model.

Parasitology 133: 139-49.

 

Fujinami, R.S., von Herrath, M.G., Christen, U. and Whitton, J.L. (2006)

Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease.

Clin Microbiol Rev.19: 80-94.

Barral, A.M., Thomas, H.E., Ling, E.M., Darwiche, R., Rodrigo, E., Christen, U., Ejrneas, M., Wolfe, T., Kay, T.W., and von Herrath, M.G. (2006)

SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes.

J. Autoimm. 27: 166-173.

Rhode, A., Pauza, M., Barral, A., Oldstone, M.B.A., von Herrath, M.G., and Christen, U. (2005)

 Islet-specific expression of IP-10 (CXCL10) targets lymphocytes to the pancreas and accelerates type 1 diabetes.

J. Immunol. 175: 3516-3524.

Hintermann, E., Yang, N., O’Sullivan, D., Higgins, J.M., and Quaranta, V. (2005)

Integrin alpha6beta4/erbB2 complex inhibits haptotaxis by upregulating E-cadherin cell-cell junctions in keratinocytes.

J. Biol. Chem. 280: 8004-8015.

Christen, U. (2005)

Meeting report: Vaccination, infection and autoimmunity: Myth and Reality. VIAMR 2005, Lausanne, Switzerland.

Investigational Drug Database (IDDB) Published online: www.iddb.com RF635148

 

Christen, U. and von Herrath, M.G. (2005)

Infection and Autoimmunity.

J. Immunol. 174 (12): 7481-7486.

Christen, U. and von Herrath, M.G. (2005)

Viruses as initiators, accelerators or terminators of autoimmunity? – A question of time and location of infection.

In: Autoimmune Liver Disease – Proceedings of the Falk Symposium 142

 

Ejrnaes, M., Videbaek, N., Christen, U., Michelsen, B., and von Herrath, M. G. (2005)

Different Diabetogenic Potential of Autoaggressive CD8+ Clones Associated with CXCL10 Production but not Cytokine Expression, Cytolytic Activity or Homing Characteristics.

J. Immunol. 174: 2746-2755.

Christen, U., Edelmann, K., McGavern, D. B., Wolfe, T., Rodrigo, E., Coon, B., Oldstone, M. B. A. and von Herrath, M. G. (2004)

A viral epitope that mimics a self-antigen can accelerate but not initiate disease.

J. Clin. Invest. 114: 1290-1298.

Christen, U. and von Herrath, M.G. (2004)

Initiating Autoimmunity.

Curr. Opin. Immunol 16 (6) 759-767.
 

Madakamutil, L. T., Christen, U., Lena, C. J., Wang-Zhu, Y., Attinger, A., Sundarrajan, M., Ellmeier, W., von Herrath, M. G., Jensen, P., Littman, D. R. and Cheroutre, H. (2004)

CD8aa-mediated survival and differentiation of CD8 memory T cell precursors.

Science 304: 590-593.
 

Christen, U., Wolfe, T., Rodrigo, E., Chervonsky, A., Flavell, R. A., and von Herrath, M. G. (2004)

Virally induced inflammation triggers fratricide of FAS-L expressing b-cells.

Diabetes 53: 591-596.

Christen, U. and von Herrath, M.G. (2004)

IP-10 and Type 1 Diabetes: A Question of Time and Location.

Autoimmunity 39 (4): 273-282.


Christen, U. and von Herrath, M. G. (2004)

Manipulating the Type 1 vs. Type 2 Balance in Type 1 Diabetes.

Immunol Res. 30: 309-325.
 

Christen, U., Benke, D., Wolfe, T., Rodrigo, E., Rhode, A., Hughes, A. C., Oldstone, M. B. A., and von Herrath, M. G. (2004)

Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient.

J. Clin. Invest.113: 74-84.
 

Christen, U., Juedes, A., Homann, D., and von Herrath., M. G. (2004)

Virally induced inflammation and therapeutic avenues in type 1 diabetes.

Endocrinol Metab Clin North Am. 33:45-58.

Hintermann, E., and Quaranta, V. (2004)

Epithelial cell motility on laminin-5: regulation by matrix assembly, proteolysis, integrins and erbB receptors.

Matrix Biol. 23(2): 75-85.

Christen, U. and von Herrath, M. G. (2004)

Induction, Acceleration or Prevention of Autoimmunity by Molecular Mimicry.

Mol. Immunol. 40: 1113-1120.
 

Christen, U., Wolfe, T., Moehrle, U., Hughes, A. C., Rodrigo, E., Green, A., Flavell, R. A., and von Herrath, M. G. (2001)

A Dual Role for TNFa in Type 1 Diabetes: Islet Specific Expression Abrogates the Ongoing Autoimmune Process when Induced Late but not Early During Pathogenesis.

J. Immunol. 166: 7023-7032.

  

Hintermann, E., Dorfleutner, A., Tarui, T., Takada, Y., and Ruf, W. (2004)

Cross-talk of integrin alpha3beta1 and tissue factor in cell migration.

Mol. Biol. Cell. 15(10): 4416-4425.

Janssen, E. M., Lemmens, E. E., Wolfe, T., Christen, U., von Herrath, M. G., and Schoenberger, S. P. (2003)

CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes.

Nature 421: 852-856.
 

Schenk, S., Hintermann, E., Bilban, M., Koshikawa, N., Hojilla, C., Khokha, R., and Quaranta, V. (2003)

Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution.

J. Cell Biol. 161(1): 197-209.

Christen U. and von Herrath, M. G. (2003) Cytokines and chemokines in virus-induced autoimmunity. Adv. Exp. Med. Biol. 520:203-220.

Bilban, M., Ghaffari-Tabrizi, N., Hintermann, E., Bauer, S., Molzer, S., Zoratti, C., Malli, R., Sharabi, A., Hiden, U., Graier, W., Knoefler, M., Andreae, F., Wagner, O., Quaranta, V., and Desoye, G. (2003)

Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiologic invasion inhibitor of primary human trophoblasts.

J. Cell Sci. 117(8): 1319-1328.

Christen, U., and von Herrath, M. G. (2002)

Transgenic animals models for type 1 diabetes: Linking a tetracycline inducible promotor with a virus-inducible mouse model.

Transgenic Research11: 587-595.
 

Christen, U., and von Herrath, M. G. (2002)

Apoptosis of autoreactive CD8 lymphocytes as a potential mechanism for the abrogation of type 1 diabetes by islet-specific TNF-a expression at a time when the autoimmune process is already ongoing.  Ann. N. Y. Acad. Sci. 958: 166-169.

McGavern, D., Christen, U., and Oldstone, M. B. A. (2002)

Molecular anatomy of antigen-specific CD8+ T cell engagement and synapse formation in vivo.

Nat. Immunol. 3: 918-925.
 

Hintermann, E., Haake, S.K., Christen, U., Sharabi, A., and Quaranta, V. (2002)

Discrete proteolysis of focal contact and adherens junction components in Porphyromonas gingivalis-infected oral keratinocytes: a strategy for cell adhesion and migration disabling.

Infect. Immun. 70: 5846-5856.


Christen, U., Wolfe, T., Moehrle, U., Hughes, A. C., Rodrigo, E., Green, A., Flavell, R. A., and von Herrath, M. G. (2001)

A Dual Role for TNFa in Type 1 Diabetes: Islet Specific Expression Abrogates the Ongoing Autoimmune Process when Induced Late but not Early During Pathogenesis.

J. Immunol. 166: 7023-7032.
 

Hintermann, E., Bilban, M., Sharabi, A., and Quaranta, V. (2001)

Inhibitory role of a6b4-associated erbB-2 and phosphoinositide 3-kinase in keratinocyte haptotactic migration dependent on a3b1 integrin.

J. Cell Biol. 153(3): 465-478.

Liu, R., Hintermann, E., Erb, C., Tanner, H., Flammer, J., Eberle, A.N., and Haefliger I.O. (2001)

Modulation of Na/K-ATPase activity by isoproterenol and propranolol in human non-pigmented ciliary epithelial cells.

Klin. Monatsb.l Augenheilkd. 218(5): 363-5.

 

Gesemann, M., Litwack, E. D., Lee, K. T., Christen, U., and O’Leary, D. D. (2001)

Identification of candidate genes for controlling development of the basilar pons by differential display PCR.

Mol. Cell. Neurosci. 18: 1-12.
 

Hintermann, E., Tanner H., Talke-Messerer, C., Schlumberger, S., Zumsteg, U., and Eberle, A.N. (2001)

Interaction of melanin-concentrating hormone (MCH), neuropeptide E-I (NEI), neuropeptide G-E (NGE), and alpha-MSH with melanocortin and MCH receptors on mouse B16 melanoma cells.

J. Recept.Signal. Transduct. Res. 21(1): 93-116.

 

da Silva Correia J., Soldau K., Christen U., Tobias P.S., Ulevitch R.J. (2001)

Lipopolysaccharide is in Close Proximity to Each of the Proteins in Its Membrane Receptor Complex: Transfer from CD14 to TLR4 and MD-2.

J. Biol. Chem. 276: 21129-21135.
 

Von Herrath, M. G., Oldstone, M. B. A., Homann, D., and Christen, U. (2001)

Is Activation of Autoreactive Lymphocytes always Detrimental? Viral Infections and Regulatory Circuits in Autoimmunity.

Curr. Dir. Autoimm. 4: 91-122.

 

Christen, U., Wolfe, T., and von Herrath, M. G. (2001)

How viral infections and/or inflammation can emhance as well as abrogate autoimmunity: A double edged sword.

Recent Res. Devel. Virol.3: 325-339.
 

Hintermann, E., Erb, C., Talke-Messerer, C., Liu, R., Tanner, H., Flammer, J., and Eberle, A.N. (2001)

Expression of the melanin-concentrating hormone receptor in porcine and human ciliary epithelial cells.

Invest. Ophthalmol. Vis.Sci. 42(1): 206-9.

1991 - 2000 


Christen, U. (2000)

Cost of institute was small change for Roche.

Nature 406: 455.
 

Seewaldt, S., Thomas, H. E., Ejrnaes, M., Christen, U., Wolfe, T., Rodrigo, E., Coon, B., Michelsen, B., Kay, T. W. H., and von Herrath, M. G. (2000)

 Virus-induced autoimmune diabetes: Most b-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.

Diabetes 49: 1801-1809.


Bot, A., Holz, A., Christen, U., Wolfe, T., Tenmann, A., Flavell, R. A., and von Herrath, M. G. (2000)

Local IL-4 expression in the lung reduces pulmonary influenza-virus-specific secondary cytotoxic T cell responses.

Virology  269: 66-77.
 

Amherd, R., Hintermann, E., Walz, D., Affolter, M., and Meyer UA. (2000)

Purification, cloning, and characterization of a second arylalkylamine N-acetyltransferase from Drosophila melanogaster

DNA Cell Biol. 19(11): 697-705.

 

Christen, U., Thuerkauf, R., Stevens, R., and Lesslauer, W. (1999)

Immune response to a recombinant human TNFR55-IgG1 fusion protein in rhematoid arthritis (RA) and multiple sclerosis (MS) patients: Auto-antibodies have neither neutralizing nor agonist activities.

Hum. Immunol. 60: 774-790.
 

Christen, U., Thuerkauf, R., and Lesslauer, W. and the Lenercept® Rheumatoid Arthritis and Multiple Sclerosis Study Groups (1998)

 Antibody response to a recombinant human TNF receptor-immunoglobulin fusion protein (TNFR55-IgG1) in rheumatoid arthritis (RA) and multiple sclerosis (MS) patients.

Roche Research Report B-169’977.

Christen, U., Thuerkauf, R., and Lesslauer, W. (1998)

 Binding of TNFR55-IgG1 (Tenefuse ®, Ro 45-2081) to human cells.

Roche Research Report B-169’135.

Steinmetz, M.O., Plüss, C., Christen, U., Wolpensinger, B., Lustig, A., Werner, E.R., Wachter, H., Engel, A., Aebi, U., Pfeilschifter, J. and Kammerer, R.A. (1998)

Rat GTP Cyclohydrolase I is a homodecameric protein complex containing high-affinity EF-hand-like Calcium-binding sites.

J. Mol. Biol. 279: 189-199.
 

Christen, U., Baudin, M., Birnböck, H., Dumont, E., Gallati, H., Lötscher, H.R., Zaug, M. and Lesslauer, W. (1996)

Preliminary report on the anti-Ro 45-2081 antibody response in rheumatoid arthritis patients of studies BK 14680 and BM 14752.

Roche Research Report B-166’394.

Gut, J., Christen, U., Frey, N., Koch, V., and Stoffler, D. (1995)

Molecular mimicry in halothane hepatitis.

Toxicology (Section Immunotoxicology) 97: 199-224.

 

Frey, N., Christen, U., Jenö, P., Yeaman, S.J., Shimomura, Y., Kenna, J.G., Gandolfi, A.J., Ranek, L. and Gut, J. (1995)

Protein X and the dihydrolipoamide acetyltransferase subunits of the oxoglutarate and branched chain dehydrogenase complexes molecularly mimic trifluoroacetylated proteins and are autoantigens associated with halothane hepatitis.

Chem. Res. Toxicol. 8: 736-746.

 

Christen, U., Quinn, J., Yeaman, S.J., Kenna, J.G., Clarke, J.B., Gandolfi, A.J. and Gut, J. (1994)

Identification of the dihydrolipoamide acetyltransferase subunit of the human pyruvate dehydrogenase complex as an autoantigen in halothane hepatitis: Molecular mimicry of CF3CO-lysine by lipoic acid.

Eur. J. Biochem. 223: 1035-1047.
 

Gut, J., Christen, U. and Huwyler, J. (1993)

 Mechanisms of halothane toxicity: Novel insights.

Pharmac. Ther. 58: 133-155.

 

Christen, U., Jenö, P. and Gut, J. (1993)

Halothane metabolism: The dihydrolipoamide acetyltransferase subunit of the pyruvate dehydrogenase complex molecularly mimics trifluoroacetyl-protein adducts.

Biochemistry 32: 1492-1499.
 

Huwyler, J., Aeschlimann, D., Christen, U. and Gut, J (1992)

The kidney as a novel tissue for protein adduct formation associated with metabolism of halothane and the candidate chlorofluorocarbon replacement 2,2-dichloro-1,1,1-trifluoroethane.

Eur. J. Biochem. 207: 229-238.

Gut, J., Christen, U., Huwyler, J., Bürgin, M. and Kenna, J.G. (1992)

Molecular mimicry of trifluoroacetylated human liver protein adducts by constitutive proteins and immunochemical evidence for its impairment in halothane hepatitis.

Eur. J. Biochem. 210: 569-576.
 

Christen, U., Bürgin, M. and Gut, J. (1991)

Halothane metabolism: Immunochemical evidence for molecular mimicry of trifluoroacetylated liver protein adducts by constitutive polypeptides.

Mol. Pharmacol.40: 390-400.
 

Christen, U., Bürgin, M. and Gut, J. (1991)

Halothane metabolism: Kupffer cells carry and partially process trifluoroacetylated protein adducts.

Biochem. Biophys. Res. Commun. 175/1: 256-262.